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Kerppola Lab Research on Protein Modifications

We have developed new methods for visualization of modified proteins in living cells. The ubiquitin-mediated fluorescence complementation (UbFC) analysis enables simultaneous imaging of specific ubiqutin and SUMO conjugates in the normal cellular environment (Fang, 2004).
By visualizing the fluorescence of UbFC ubiquitin conjugates in living cells, we found that  ubiquitinated Jun is translocated into lysosomes (Ikeda, 2008).