Kerppola Lab Research on Protein Modifications

By visualizing the fluorescence of UbFC ubiquitin conjugates in living cells, we found that  ubiquitinated Jun is translocated into lysosomes (Ikeda, 2008).

We have developed new methods for visualization of modified proteins in living cells. The ubiquitin-mediated fluorescence complementation (UbFC) analysis enables simultaneous imaging of specific ubiqutin and SUMO conjugates in the normal cellular environment (Fang, 2004).